Silk in Tinderbox
I've been experimenting with Unsanity Software's freeware Silk, a small extension to MacOS X 10.1.5 that adds text smoothing to a host of applications, including Tinderbox. It's a small extension to System Preferences, and seems both flexible and trouble-free.
At first, the apparennt fuzziness of anti-aliased type may be slightly unsettling, but in time it simply looks better. (Do make sure your font settings are large enough for you to read comfortably!)